The research delves into how mutations in FGFR2 and FGFR3 affect mandibular bone formation and endochondral bone repair following non-stabilized fractures. The findings reveal that FGFR ...

ALLELIC TWINS: Jackson-Weiss and Crouzon syndromes are both caused by FGFR2 mutation, notes Johns Hopkins researcher Ethylin Jabs. E.W. Jabs, X. Li, A.F. Scott, G ...

A diagnostic for FGFR2 mutations from Nihon Stery has also been approved for use alongside the drug treatment. Tasfygo was given a priority review in Japan, reflecting the relatively high ...

Using mouse models of Crouzon syndrome (Crz) and hypochondroplasia (Hch), the researchers examined the impact of FGFR2 and FGFR3 mutations on mandibular bone formation and repair. They discovered ...

Hypomethylation on fibroblast growth factor receptor 2 (FGFR2), a receptor tyrosine kinase (RTK) oncogene, increased transcript and protein abundance and drove cancer activity. Genetic mutations in ...

Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. The company also has an ongoing ...

BALVERSA (erdafitinib) has strong market potential in the FGFR-altered urothelial carcinoma space, particularly as a targeted therapy for patients wi ...

as a treatment for biliary tract cancers with FGFR2 gene fusion mutations. The application to the Ministry of Health, Labour and Welfare (MHLW) is set for a priority review, reflecting the ...