Breakthrough combination therapy tackles drug resistance in lung cancer with common KRAS mutation
A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have ...
Hosted on MSN1mon
Hit and Miss for CDK4/6 Inhibitor in Recurrent Brain Cancer
"Targeted ERK inhibition remains an unmet need in experimental glioblastoma therapy." The study by Brastianos' group was supported by the National Cancer Institute and Eli Lilly. Brastianos ...
Medscape5d
Clinical Overview of Sorafenib in Breast Cancer
Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...
mskcc.org8y
The Neal Rosen Lab: Research Overview
The laboratory is studying the role of Hsp90 family members in maintaining the transformed phenotype of cancer cells. Our recent work has shown that Hsp90 is critical for oncogenic RAF kinase-driven ...
Pulmonary Hypertension News4d
MTMR7 protein shows promise as PAH treatment in mice
Boosting MTMR7 production reversed signs of pulmonary arterial hypertension in a mouse model of PAH and may serve as a ...
eLife12d
Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis
Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy ...