Scientists apply principles of math and physics to unravel the mystery of how the endoplasmic reticulum, an organelle vital ...

The peripheral endoplasmic reticulum (ER) forms a continuous ... Investigating how the unique structure of the ER arises and supports its function is critical to developing a mechanistic ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are ...

The structure of CRT suggested that it has ... is considered a characteristic quality control process of the endoplasmic reticulum), and ii) CRT regulates intracellular calcium levels, acting ...

The new research finds that the endoplasmic reticulum and the plasma membrane form contact sites where specialized molecules control the release of calcium, which regulates the signals sent along ...

The Jokitalo group studies structure-function interplay of organelles in mammalian cells. Our main model organelle is the endoplasmic reticulum. We employ a wide range of basic biological techniques ...

By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

Our research focuses on studies on the molecular structure and mechanism of proteins, recently mostly on the endoplasmic reticulum proteins involved in cellular stress signalling, including in ...

Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism ... where the lipid concentration, composition or both are altered 26,31. Exposure to such a lipotoxic ...