July 1, 2013 (Vol. 33, No. 13). The current discussion of downstream bottlenecks arises from the ease with which up-stream activities generate protein and the desire for downstream operations to ...

Downstream bioprocessing is shunning “stop and go” in favor of “go with the flow.” How? It’s using process intensification to coordinate or even combine well-established operations.

Downstream processing continues to be a significant pain point for contract manufacturing organizations (CMOs), and downstream-fueled bottlenecks don’t appear to show any signs of abating, according ...

Table 2 Challenges of downstream processing to produce large amounts of MAbs, addressed by second-generation, high flow agarose protein A resins. Cleaning and sanitization The potential for carryover ...