Replicase (Rep) Proteins: Enzymes that initiate and facilitate the replication of viral DNA, often belonging to the HUH endonuclease superfamily. Circular Single-Stranded DNA Viruses Publication Trend ...

We've known that circular RNAs show up in DNA viruses like Epstein-Barr and the human papillomavirus, but seeing that they are generated by an RNA virus like HIV-1 is incredibly exciting.