Main Implications “Both the presence and absence of tumor hypoxia may serve as biomarkers to guide personalized treatment plans for patients with HNSCC,” said Dr. Lee. “Patients with a higher distant ...

Chemokines are a subset of cytokines that cause immune cell migration. The chemokine CXCL16 recruits T cells, the white blood cells that help fight infection and cancer, to infiltrate cells.

The bacteria release chemokines that attract ‘killer’ T cells and dendritic cells into the tumor, harnessing the host’s natural antitumor immune response. The scientists hope that this approach could ...

Reeves, K.M., et al. (2021) 18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 ...

Chemokines can also serve as a line of communication between cells in the body. CXCL12 connects cancer cells to stromal cells facilitating metastatic spread of cancer. A recent report published in the ...

de la Calle-Fabregat, C., et al. (2024) NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment. Science Advances ...

These immunosuppressive effects, the team found, were heightened in hypoxic (oxygen-deprived) environments like the hypoxic regions within the tumor where CD71+ neutrophils occur.

The aging process is accompanied by changes in the tumor microenvironment, including the stiffening of the extracellular matrix and the accumulation of inflammatory immune mediators, such as ...

However, T cells’ “noses” often cannot pick up the scent of cancer cells, i.e., T cells do not express the receptors, which recognize the chemokines secreted by tumors.

Chemokines are proteins secreted by cells in the body, such as tumor cells, to attract immune cells. Homing happens when the bone's scent reaches the dog -- it will zero in on the bone's location ...