Misalignment between the central circadian clock and daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal misalignment between central and peripheral ...

This phenomenon highlights the importance of the peripheral clock, which not only receives signals from the central clock - which coordinates the rhythms of the entire organism - but also adapts ...

Central and peripheral tolerance processes regulate T cell specificity and activation. Thymus exhibits a remarkable example of central tolerance during the initial stages of T-cell development ...

In adults, particularly after HSCT, central tolerance is lost because of involution of the thymus gland and peripheral tolerance becomes the main mechanism for control.

Arvinas Presents First-in-Human Data for Investigational Oral PROTAC ARV-102 Demonstrating Blood-Brain Barrier Penetration, and Central and Peripheral LRRK2 Degradation ...