Summary: Maraviroc is the first CCR5 coreceptor antagonist to receive marketing approval from the Food and Drug Administration (FDA) for the treatment of CCR5-tropic human immunodeficiency virus ...

ASSAY ACE: Aaron Diamond's Alexandra Trkola helped develop an assay that characterized the binding mechanisms of the CCR5 coreceptor, which HIV uses, along with CD4, to gain initial entry into cells.

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...