The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

This image shows CCR5 side-by-side with alternate HIV co-receptor CXCR4. While the two share similar overall architecture, their binding pockets show important differences in shape and charge ...

Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...

Computational analysis of the variations in the HIV-1 genome sequence that correlate with preferential binding to the CCR5 (C-C-motif receptor 5) or CXCR4 (C-X-C motif receptor 4) coreceptors in ...

Experiments using cells that expresses both CXCR4 and CCR5, such as human peripheral blood mononuclear cells, rarely result in the selection of drug-resistant viruses that change coreceptor usage.