Lowe's first big break came in 1994 as the voice of Space Ghost on Cartoon Network's 'Space Ghost Coast to Coast.' ...

The kind of show where Busta Rhymes, Space Ghost, and his sidekicks can stage a murder mystery before getting high off natural gas and ending up in a spaceship crash that ends in a grocery store ...

The show was a parody of talk shows, hosted by the Hanna-Barbera character Space Ghost, and featured live-action celebrity guests, including Busta Rhymes, Willie Nelson, and Raven-Symoné.