Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

Researchers discovered a mechanism after acute liver damage occurs—and it could lead to treatments for those with severe ...

is a chemically modified bile acid that has already shown promising results in the treatment of liver diseases such as primary sclerosing cholangitis (PSC) and is being tested in clinical studies.

A type of bile ... acid, or LCA, in genetically modified mice with human tissues and compared them to calorie restriction.

One of the hallmarks of UC is a deficiency in certain bile acids, molecules that help digest fats and regulate gut health. These molecules aren't just produced by the liver—they are further ...

is a chemically modified bile acid that has already shown promising results in the treatment of liver diseases such as primary sclerosing cholangitis (PSC) and is being tested in clinical studies.

is a chemically modified bile acid that has already shown promising results in the treatment of liver diseases such as primary sclerosing cholangitis (PSC) and is being tested in clinical studies.

We quickly realized that, unlike most conjugated bile acids, these MCBAs originated from gut microbes rather than the liver. Biology doesn’t just happen; there is likely some selective pressure ...

Liver disease patients waiting for a transplant have been offered fresh hope. A new mechanism for rapid liver regeneration ...

The liver is a vital organ, crucial to digestion, metabolism and the elimination of toxins. It has a unique ability, regeneration, which allows it to replace liver cells damaged by the very toxins ...

Researchers have now determined that hepatic stellate cells control liver metabolism as well as liver regeneration and size ... cholangiocytes transport bile, and Kupffer cells act as a protective ...