The effect on the distal tubule is not dependent on carbonic anhydrase or aldosterone’s inhibitory effect. The therapy is contraindicated in individuals with anuria or with a history of ...

By competing with aldosterone for receptor sites in distal renal tubules, spironolactone increases sodium chloride and water excretion while conserving potassium and hydrogen ions. The inhibition ...

b Due to production of non-aldosterone mineralocorticoids ... g Due to increased activity of Na-Cl co-transporter in the distal tubule. h Specific for underlying mechanisms (other forms of ...

Elevated aldosterone stimulates sodium reabsorption ... sodium chloride cotransporters in certain parts of the distal convoluted tubule. Gitelman syndrome is caused by a genetic mutation that ...