Head writer Jeff Trammell and supervising director Mel Zwyer pay homage to the early comics with a "moving comic" style in CG while introducing a surprising supporting cast.

But the most similar origin story to the one shown in Your Friendly Neighborhood Spider-Man is actually that of Miles Morales in Spider-Man: Into the Spider-Verse, where he’s bitten by a spider from a different dimension.

In the MCU, Peter Parker's billionaire mentor was Iron Man. But in Your Friendly Neighborhood Spider-Man, Peter's mentor is not as friendly.