North Henderson is a village in Mercer County, Illinois, United States. The population was 162 at the 2020 census. North Henderson is located in southeastern Mercer County at 41°5′23″N 90°28′31″W / 41.08972°N 90.47528°W. It is 21 miles southeast of Aledo, the county seat, and 14 miles northwest of Galesburg.