Guys is a town in McNairy County, Tennessee. The population was 466 at the 2010 census. Guys is located at 35°1′23″N 88°32′48″W / 35.02306°N 88.54667°W. According to the United States Census Bureau, the town has a total area of 11.7 square miles, of which 11.7 square miles is land and 0.04 square miles is water.